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Hiltonol Mimics Nature by Combining the Essential Elements of Human Immunity

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Hiltonol® is a synthetic dsRNA viral mimic and host-defense activator

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• Hiltonol’s® tumor pro-apoptotic effect induces tumor antigen and neoantigen expression

  • Promotes induction of natural killer cells and dsRNA dependent systems (OAS, PKR)

• Hiltonol® is the preferred critical 'Danger Signal', or Immune Adjuvant  for Cancer Vaccines

  • §Mechanisms include TLR3 and MDA5 mediated systems

• Hiltonol® induces killer-cell targeting (chemotaxis) and tumor vascular endothelial infiltration

• Hiltonol® supports the hosts ability to overcome immune suppression ‘checkpoints’ in the tumor microenvironment

  • Via CD8 boost with aPD-1 and APD l-1 checkpoint blockers

• Hiltonol® activates Immunological memory, facilitating durable tumor responses